COVID-19 probably came to people through an animal, and likely started spreading no more than a month or two before it was noticed in December 2019, a World Health Organisation (WHO) draft report finds.
The least likely source: a laboratory leak, the WHO's joint international team concluded.
The WHO is scheduled to release the final report on its investigation into the origins of coronavirus on Tuesday, but a draft version of the report obtained by CNN shows there's still no smoking gun and no evidence suggesting the virus was spreading any earlier than the very end of 2019.
The report gives four possible sources for the virus and the most likely scenario is via an intermediate animal host, possibly a wild animal captured and then raised on a farm.
But the investigation has not found whether any other animal was infected by a bat – considered the most likely original source of the virus – and then may have transmitted it to a human.
"The possible intermediate host of SARS-CoV-2 remains elusive," it reads.
Next likely is direct transmission from one of the animals known to carry a similar coronavirus, such as a bat or a pangolin. Possible but not probable is transmission from frozen or chilled food, and least likely is an accidental laboratory release, the report finds.
Former United States (US) Centers for Disease Control and Prevention (CDC) Director Dr Robert Redfield told CNN’s Dr Sanjay Gupta that his personal opinion was the virus was released from a lab.
The report says this is "extremely unlikely."
"There is no record of viruses closely related to SARS-CoV-2 in any laboratory before December 2019, or genomes that in combination could provide a SARS-CoV-2 genome," it reads. "In view of the above, a laboratory origin of the pandemic was considered to be extremely unlikely."
Independent researchers have been saying this for months. Genomic testing of the virus indicates it was not engineered in a lab but passed naturally from animals – as did the SARS virus that infected 8,000 people globally in 2002-2004 before it was stopped.
The role of the Huanan seafood market in Wuhan is also unclear. It's possible the market was not the original source of the outbreak, but that the crowds that gathered at the market – which was densely packed, with a roof and open sewers – may have amplified the spread of the virus.
Sampling at the market turned up the virus on surfaces but not in samples taken from animals or food sold at the market. Plus, there is evidence the virus was circulating before the Huanan market outbreak – including at other markets.
"Many of the early cases were associated with the Huanan market, but a similar number of cases were associated with other markets and some were not associated with any markets. Transmission within the wider community in December could account for cases not associated with the Huanan market which, together with the presence of early cases not associated with that market, could suggest that the Huanan market was not the original source of the outbreak," the report added.
The report recommends more testing of blood samples taken and stored before the first outbreak in December, more testing of animals from Southeast Asia, and a more in-depth study of mass gatherings that could have aided the spread of the virus.
The report was written by a joint international team made up of 17 Chinese experts plus 17 experts from other countries, the WHO, the Global Outbreak Alert and Response Network (GOARN) and the World Organisation for Animal Health (OIE). The United Nations Food and Agriculture Organization (FAO) participated as an observer.
"Following initial online meetings, a joint study was conducted over a 28-day period from 14 January to 10 February, 2021 in the city of Wuhan, in the People's Republic of China," the report reads.
The team looked for evidence if the virus was circulating in China before anyone noticed.
"The epidemiology working group closely examined the possibilities of identifying earlier cases of COVID-19 through studies from surveillance of morbidity (illness) due to respiratory diseases in and around Wuhan in late 2019," it read.
"It also drew on national sentinel surveillance data; laboratory confirmations of disease; reports of retail pharmacy purchases for antipyretics (fever reducers), cold and cough medications; a convenience subset of stored samples of more than 4,500 research project samples from the second half of 2019 stored at various hospitals in Wuhan, the rest of Hubei Province and other provinces.”
“In none of these studies was there evidence of an impact of the causative agent of COVID-19 on morbidity in the months before the outbreak of COVID-19."
The report suggests further checks into farms as a possible source of the virus.
Animals such as mink and rabbits are susceptible to the virus, the report noted. Mink farms in several countries have been the cause of outbreaks of COVID-19.
United States (US) White House press secretary Jen Psaki said the report is being reviewed by federal government agencies, including the CDC, the Food and Drug Administration, the National institutes of Health and others. Psaki said those public health experts "will be reviewing this report intensively and quickly." - CNN
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